Can we install cracked softwares in a virtual box guest OS and keep the host OS intact?

Can we install cracked softwares in a virtual box guest OS and keep the
host OS intact?

I want to root my android phone but it seems the root tools often contain
virus/trojan.
I wonder if I would install and use those tools in a virtual guest OS
machine, e.g. VirtualBox from Oracle, and keep my PC the host OS machine
safe from virus?